Neurodegenerative disorders are related to the progressive loss of structure or function and, eventually, death of neurons. These\nprocesses are responsible for diseases like Parkinson�s, Alzheimer�s, and Huntington�s, and the main molecular target for the drug\ndesign against these illnesses today is the enzyme acetylcholinesterase (AChE). Following this line, in the present work, we applied\ndocking techniques to study some piperidine derivative inhibitors of AChE and further propose structures of six new AChE\ninhibitors as potential new drugs against neurodegenerative disorders. The best inhibitor proposed was submitted to additional\nmolecular dynamics simulations steps.
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